Clinical Study Summary - Ashwagandhadi Lehya (Pilot Clinical Evaluation)

Publication:

Research Journal of Pharmacy & Technology (RJPT)
Volume 12, Issue 5, Year 2019
DOI: 10.5958/0974-360X.2019.00399.8

 

Objective

The study aimed to clinically evaluate the classical Ayurvedic formulation Ashwagandhadi Lehya for its aphrodisiac, spermatogenic & hormone-modulating effects, specifically in the management of oligospermia (low sperm count) & reduced male sexual performance.
The investigation assessed semen parameters, testosterone, FSH, LH & sexual function using a standardized questionnaire.

 

Methodology

• Study type: Pilot clinical trial
• Duration: 90 days
• Assessments conducted at: Day 0, Day 45, Day 90

Parameters evaluated:

1. Hormonal profile: Serum FSH, LH & testosterone
2. Semen analysis:
• Sperm concentration
• Percentage of normal sperm
• Percentage of motile sperm
3. Sexual function:
   Evaluated using a questionnaire based on the International Index of Erectile Function (IIEF-5), covering desire, erection, rigidity, ejaculation & orgasm.

Routine biochemical & haematological tests were also performed to monitor safety.

 

Results

Hormone Changes

• Serum testosterone increased by:
• ~8.31% at 45 days
• ~16.53% at 90 days
• FSH & LH did not increase, suggesting that the formulation stimulated testicular testosterone production directly.

Semen Quality

After 90 days of treatment:

• Sperm concentration: increased by approximately 200%
• Normal sperm percentage: increased by ~11%
• Motile sperm percentage: increased by ~59%

Sexual Function

Participants reported statistically significant improvements in:

• Desire
• Erection hardness
• Penile rigidity
• Ejaculation control
• Orgasmic satisfaction

Safety

No adverse reactions or abnormal findings were observed in routine safety tests throughout the 90-day period.

 

Conclusion

The study concluded that Ashwagandhadi Lehya demonstrates significant spermatogenic, testosterone-enhancing & aphrodisiac activity.
The formulation improved sexual function, semen parameters & hormone levels safely over a 90-day period.
Because testosterone increased without parallel rises in FSH or LH, the authors proposed that the mechanism may involve direct stimulation of testicular protein expression responsible for steroid hormone synthesis.

 

Citation

Raval M., Patel M., Gamit K., Patel K., Gupta S. N.
A Pilot Study on Evaluation of Standardized Ayurvedic Formulation Ashwagandhadi Lehya as Aphrodisiac & in Treatment of Oligospermia.
Research Journal of Pharmacy & Technology. Vol 12, Issue 5, 2019.